Improved bioinformatics tools for the analysis of mass spectrometry-based peptidomics and proteomics data
نویسنده
چکیده
..................................................................................................... ii Declaration ..................................................................................................... iv Preface ..................................................................................................... vi Acknowledgements ....................................................................................... viii List of Figures ................................................................................................ xiv List of Tables ................................................................................................. xvi List of Abbreviations ................................................................................... xviii Chapter 1. Background and Literature Review ........................................... 1 1.1 Biological role of peptides ...................................................................... 2 1.2 Mass spectrometry ................................................................................. 4 1.3 Sequence databases ............................................................................. 7 1.4 Peptide Identification .............................................................................. 9 1.5 Validation, FDR estimation and decoy sequence databases ................ 15 1.6 Aims and organisation of this thesis ..................................................... 18 1.6.1 The aims of this thesis are to: .............................................................. 18 1.6.2 This thesis is organised as follows: ...................................................... 18 Chapter 2. LudwigNR: A single comprehensive, non-redundant, speciesspecific and taxonomy enabled protein sequence database for MS-based proteomics and peptidomics research ............ 21 2.
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